DLBCL {secure} | R Documentation

## Chemotherapy data

### Description

A list of two components.

### Usage

    data(DLBCL)

### Format

A list with two components:

Y

  Chromatin immunoprecipitation. A matrix of 180 rows and 661 columns.

classIndex

  Group index of 180 patients where 1,2,3 corresponds to OxPhos, BCR and HR groups respectively.

### Details

Matrix Y : Gene expression dataset from the patients with diffuse large-B-cell lymphoma (DLBCL) after chemotherapy. The data has been used for unsupervised analysis i.e. Biclustering. The data consists of expression levels of q = 661 genes from n =180 patients. Among the patients, 42, 51 and 87 of them were classified to OxPhos, BCR and HR groups, respectively. The data thus form an n by q matrix Y whose rows represent the subjects and columns correspond to the genes, and used in Rosenwald (2002).

classIndex: Out of OxPhos (oxidative phosphorylation), BCR(Bcell response) and HR (host response), the index corresponds to the groups in which these 180 subjects belongs as classified by Hoshida (2007).

### References

Rosenwald, A., Wright, G., Chan, W. C., Connors, J. M., Campo, E., Fisher, R. I., Gascoyne, R. D., Muller-Hermelink, H. K., Smeland, E. B., Giltnane, J. M. et al. (2002) The use of molecular profling to predict survival after chemotherapy for diffuse large-b-cell lymphoma. New England Journal of Medicine, 346, 1937-1947.

Hoshida, Y., Brunet, J.-P., Tamayo, P., Golub, T. R. and Mesirov, J. P. (2007) Subclass mapping: Identifying common subtypes in independent disease data sets. PLoS ONE, 2, e1195.

### Examples

    # data(DLBCL)

[Package secure version 0.5 Index]